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ICP4 is required for the expression and subsequent association of early, but not IE, viral gene products with input viral genomes. Viral-genome-associated viral proteins were detected by MS at 3 hpi with KOS-EdC or n12-EdC (MOI of 10 PFU/cell). Proteins were distinguished as either heavy (H), light (L), or intermediate (I) by SILAC analysis. See also Tables S1 and S2 and Fig. S1, S4, and S5.
