FIG 7 .

Levels of host transcription factors are selectively reduced on input viral DNA at 6 hpi. (A) Graphic illustration of predicted physical and functional interactions between human proteins that associate with HSV-1 genomes at 6 hpi with KOS-EdC (MOI of 10 PFU/cell). (B) Spectral abundance (SAF) of select viral-genome-associated host proteins that function in transcription regulation. Viral-genome-associated host proteins were detected by MS at 1, 2, 3, or 6 hpi with KOS-EdC. Proteins that associate with viral replication compartments that were labeled with EdC from 4 to 6 hpi (6 hpi + EdC) are also shown (15). Note that KDMA1 is associated with the NuRD complex but is not a core component. See also Table S2 and Fig. S3.