Table 1.

Summary of Deficits Observed on Behavioral Tasks Assessed Following Repeated Mild Closed Head Injury in C57Bl/6J and NSG Mice.

Task	Time point	Strain	Sham (n)	1 Hit at 5.0 m/s	5 Hits at 2.5 m/s	5 Hits at 5.0 m/s	10 Hits at 5.0 m/s	Significant deficit	Summary
Rotarod	1, 4, 10, 21, 35 DPI	C57BL/6 mice	14	11	–	9	13	No	Deficits at 1 DPI for 10-hit group: 10 vs. sham
Horizontal ladder beam	1 MPI	C57BL/6 mice	14	11	–	9	13	No	N.S.
Tail suspension test	1 MPI	C57BL/6 mice	14	11	–	9	13	No	N.S.
Elevated plus maze (bright room)	1 MPI	C57BL/6 mice	14	11	–	9	13	Yes	10 Hits and 5 hits vs. 1 and sham: more time in open arm, more distance traveled, more open arm entries; closed arm entries (N.S.)
Elevated plus maze (dark room)	1 MPI	C57BL/6 mice	8	11	–	–	9	Yes	10 Hits vs. 1 and sham: more time in open arm, trend for more distance traveled (N.S.)
Elevated plus maze (dark room)	1 MPI	C57BL/6 mice	12	–	12	12	–	Yes	Time in open arms: 5 hits at 5.0 m/s > 3 hits at 5.0 m/sTime in open arms: 5 hits at 5.0 m/s > 5 hits at 2.5 m/sTime in open arms: 5 hits at 5.0 m/s > shamTime in open arms: 3 hits at 5.0 m/s > sham
Morris water maze	2 MPI	C57BL/6 mice	14	11	–	9	13	Yes	10 Hits and 5 hits vs. 1 and sham: deficits in learning platform location (latency to reach platform), decreased distance traveled in probe, decreased platform crossings in probe, decreased time in target quadrant in probe
Morris water maze	2 MPI	C57BL/6 mice	12	–	12	12	–	Yes	Learning deficits at D4 and D5 trainingSham ≤ 5 hits at 2.5 m/s < 3 hits at 5.0 m/s ≤ 5 hits at 5.0 m/s
Forced swim test	2 MPI	C57BL/6 mice	8	11	–	–	9	Yes	10 Hits vs. 1 and sham: less time “immobile,” more time “high mobility”
Elevated plus maze (dark room)	6 MPI	C57BL/6 mice	6	9	–	–	7	Yes	10 Hits vs. 1 and sham: more time in open arm, more distance traveled
Forced swim test	6 MPI	C57BL/6 mice	6	9	–	–	7	Yes	10 Hits vs. 1 and sham: less time “immobile,” more time “high mobility”
Morris water maze	6 MPI	C57BL/6 mice	6	9	–	–	7	Yes	10 Hits vs. 1 and sham: deficits in learning platform location (latency to reach platform);
Elevated plus maze (dark room)	1 MPI	NOD-scid gamma	12	12	12	11	–	No	N.S.
Morris water maze	1 MPI	NOD-scid gamma	12	12	12	11	–	No	N.S.
Elevated plus maze (dark room)	6 MPI	NOD-scid gamma	6	6	6	6	–	No	N.S.
Forced swim test	6 MPI	NOD-scid gamma	6	6	6	6	–	No	N.S.
Novel object recognition	6 MPI	NOD-scid gamma	6	6	6	6	–	No	N.S.
Novel place recognition	6 MPI	NOD-scid gamma	6	6	6	6	–	No	N.S.

Note. NSG = NOD-scid gamma mice; DPI = days postinjury; MPI = months postinjury.