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. 2018 Apr 10;2018:1821359. doi: 10.1155/2018/1821359

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Copyright © 2018 Klinsmann Carolo dos Santos et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Dose-response profile of Yacon leaves. The animals were randomly assigned to one of three groups: Y25, Y50, and Y100 (25, 50, and 100 mg/kg body weight/day of Yacon extract constituted in 1 mL of 0.9% saline, resp.). Diabetes mellitus was induced by one i.p. administration of streptozotocin (STZ; 40 mg/body weight), and the animals received HEYL for gavage for 15 days after the establishment of the diabetic condition and glycemia was measured at day 7 (7th d) and day 15 (15th d). C: controls; C + Y: controls treated with Yacon leaf extract; DM: diabetic controls; and DM + Y: diabetic rats treated with Yacon. The data are represented as the median. Statistical analysis was performed using the generalized linear model and one-way analysis of variance test. Significant values are represented by P < 0.05. ^∗Versus Y25; ^#versus Y50.