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Time-dependent effects of high glucose in ARPE-19 cells. (a) Time-course analysis of ROS production in ARPE-19 cells maintained under normal and high glucose conditions. (b) Time-course analysis of total DNMT activity in ARPE-19 cells maintained under normal and high glucose conditions. (c) Time-course analysis of DNMT1 expression in ARPE-19 cells maintained under normal and high glucose conditions. ∗ p < 0.05; ∗∗ p < 0.01; ∗∗∗ p < 0.001.
