Table 1.
The studies included in the final review.
| Study | Pang et al. [19] | Temmerman et al. [20] |
|---|---|---|
| Methods | Randomized controlled clinical trial | Randomized controlled clinical split mouth trial |
|
| ||
| Participants | 60 patients | 22 patients |
|
| ||
| Surgical considerations | Extraction with two vertical releasing incisions (mesial/distal) plus collagen membrane with DBB collagen sponge | Extraction plus 2-3 PRF |
|
| ||
| Intervention | Test group: deproteinized collagen bovine bone covered with collagen membrane | Test group: leukocyte-platelet-rich fibrin |
| Control group: spontaneous healing | Control group: spontaneous healing | |
| Level A buccal defects: between 3 and 5 mm | ||
| Level B buccal defects: 5 mm or more | ||
|
| ||
| Measurement method | CBCT/ISQ | CBCT |
|
| ||
| Follow-up | 6 months postoperatively | 3 months postoperatively |
|
| ||
| Outcome | Vertical resorption: | Vertical resorption (lingual): |
| (i) Level A (control group): −2.92 ± 0.31 mm | −0.7 ± 0.8 mm (control group) | |
| (ii) Level A (test group): −1.53 ± 0.26 mm | −0.3 ± 1.2 mm (L-PRF group) | |
| (iii) Level B (control group): −3.17 ± 0.37 mm | Vertical resorption (buccal): | |
| (iv) Level B (test group): −2.48 ± 0.22 mm | −1.6 ± 1.2 mm (control group) | |
| −0.1 ± 1.6 mm (L-PRF group) | ||
| Horizontal resorption: | Horizontal resorption (lingual): | |
| (i) Level A (control group): −3.26 ± 0.44 mm | (Control group) | |
| (ii) Level A (test group): −2.87 ± 0.25 mm | HW-1 mm: −2.0 ± 2.6 mm | |
| (iii) Level B (control group): −3.82 ± 0.33 mm | HW-3 mm: −0.2 ± 0.3 mm | |
| (iv) Level B (test group): −3.05 ± 0.18 mm | HW-5 mm: −0.1 ± 0.3 mm | |
| (Test group) | ||
| HW-1 mm: −0.3 ± 1.9 mm | ||
| HW-3 mm: −0.1 ± 0.3 mm | ||
| HW-5 mm: −0.0 ± 0.1 mm | ||
| Mean ISQ test group: | Horizontal resorption (buccal): | |
| Immediately after implant placement: 62.33–63.40 | (Control group) | |
| 1 month postoperatively: 60 | HW-1 mm: −3.3 ± 2.6 mm | |
| 3 months postoperatively: 72 | HW-3 mm: −1.0 ± 1.1 mm | |
| HW-5 mm: −0.5 ± 0.7 mm | ||
| Mean ISQ control group: | (Test group) | |
| 1 month postoperatively:– | HW-1 mm: −1.2 ± 2.6 mm | |
| 3 months postoperatively: 70 | HW-3 mm: −0.8 ± 0.9 mm | |
| HW-5 mm: −0.5 ± 0.6 mm | ||
|
| ||
| Secondary outcome | Level B (control group): implants could not be placed in 3 patients | L-PRF group: 94.7% socket fill |
| Control group: 63.3% socket fill | ||