(b) The respective association between NASH at baseline, high NAS at baseline, and fibrosis progression per se, with mortality using Cox regression.
| Parameter | HR | 95% CI | p value | aHR1 | 95% CI | p value |
|---|---|---|---|---|---|---|
| NASH | 1.43 | 0.55–3.69 | 0.46 | 0.97 | 0.20–4.67 | 0.97 |
| NAS 5–8 | 1.02 | 0.41–2.54 | 0.97 | 0.46 | 0.12–1.69 | 0.24 |
| Fibrosis progression | 2.10 | 0.87–5.09 | 0.10 | 2.83 | 0.99–8.05 | 0.051 |
1Adjusted for sex, age, BMI, type 2 diabetes at first biopsy, and time between biopsies. Abbreviations: OR: odds ratio; aOR: adjusted odds ratio; CI: confidence interval; NASH: nonalcoholic steatohepatitis; NAS: NAFLD activity score.