Figure 4.

linc‐UFC1 modulates FOXP3 expression. A, RNA sequencing was performed. Expression heatmap of transcripts whose expressions were regulated by linc‐UFC1 knockdown. B, The mRNA level of FOXP3 expression was detected by qRT‐PCR in control and linc‐UFC1‐downregualted cells. C, The protein level of FOXP3 expression was detected by Western blot in control and linc‐UFC1 knockdown cells. D, The full‐length FOXP3 was transfected into linc‐UFC1‐silencing Hela cells. Then, the FOXP3 expression was detected by Western blot. E, Restoration of FOXP3 expression rescued the proliferation decreased by linc‐UFC1 knockdown in HeLa cells. F, Restoration of FOXP3 expression rescued the migration, and invasion decreased by linc‐UFC1 knockdown in HeLa cells. G, The correlation between linc‐UFC1 and FOXP3 expression was determined in cervical cancer tissues. Data are shown as mean ± SD; *P < .05