Table 1.

Overview of the identified hepatocellular carcinoma‐associated circRNAs

Circbase ID (Alias)	Chromosome	Strand	Gene symbol	Function	Expression change	Possible mechanism	References
hsa_circ_0001946 (ciRS‐7)	chrX	+	CDR1AS	Promotes cell proliferation and invasion	Up	miRNA sponge	22, 23, 66
has_circ_0001649	chr6	−	SHPRH	Inhibits cell proliferation	Down	miRNA spongea	62
hsa_circ_0001727	chr7	+	ZKSCAN1	Inhibits cell proliferation, migration, and invasion	Down	miRNA spongea	59
hsa_circ_0005075	chr1	−	EIF4 gG3	Promotes cell adhesion	Up	miRNA spongea	60
hsa_circ_0000284	chr11	+	HIPK3	Promotes cell proliferation	Up	miRNA sponge	48, 67
hsa_circ_0007874	chr6	+	MTO1	Inhibits cell proliferation and invasion; promotes apoptosis	Down	miRNA sponge	61
hsa_circ_0004018	chr17	−	SMYD4	Not investigated	Down	miRNA spongea	56
hsa_circ_0003570	chr10	−	FAM53B	Not investigated	Down	Not investigated	57
hsa_circ_0005986	chr1	+	PRDM2	Inhibits cell proliferation and cell cycle progression	Down	miRNA sponge	58
hsa_circ_0000130	chr1	+	SNX27	Promotes cell invasion	Up	miRNA sponge	65
hsa_circ_0085154	chr8	−	ARSP91	Inhibits colony formation and tumor growth	Down	Regulated by ADAR1	7
hsa_circ_0001445	chr4	+	SMARCA5	Inhibits proliferation and migration	Down	miRNA sponge	63
hsa_circ_0067934	chr3	+	PRKCI	Promotes tumor growth and metastasis	Up	miRNA sponge	68
hsa_circ_0001141	Chr20	+	ITCH	Not investigated	Down	Single‐nucleotide polymorphism	64

^aPrediction based on bioinformatics, not validated.