Table 1.
Clinical characteristics of 346 patients with HCC (Cohort 1 and 2) according to NEDD8 expression level
| Variables | NEDD8 | P‐value | |
|---|---|---|---|
| Low | High | ||
| All cases | 173 | 173 | |
| Age, y, ≥60:<60 | 34:139 | 41:132 | .361 |
| Gender, male/female | 132:18 | 137:19 | .962 |
| HBsAg, positive/negative | 152:21 | 147:26 | .433 |
| HBeAg, positive/negative | 27:146 | 47:126 | .009* |
| AFP, μg/L, >20:≤20 | 108:65 | 111:62 | .738 |
| Liver cirrhosis, with/without | 125:48 | 132:41 | .389 |
| Tumor number, multiple:solitary | 34:139 | 30:143 | .580 |
| Tumor size, cm, >5:≤5 | 87:86 | 88:85 | .914 |
| Edmondson’s grade, III + IV:I + II | 166:7 | 146:27 | <.001* |
| Pathological satellite, present/absent | 129:44 | 116:57 | .124 |
| Microvascular invasion, present:absent | 135:38 | 61:112 | <.001* |
| TNM stage, II + III:I | 45:128 | 34:139 | .159 |
| BCLC stage, B + C:0 + A | 34:117 | 29:127 | .394 |
AFP, alpha‐fetoprotein; BCLC, Barcelona Clinic Liver Cancer; HBsAg, hepatitis B surface antigen; HBeAg, hepatitis B e antigen; HCC, hepatocellular carcinoma; TNM, tumor‐node‐metastasis.
*P < .05 by the chi‐squared test.