Figure 2.

HMGA2 facilitates GBM cell invasion in vitro and malignancy in vivo. (A) qRT‐PCR and Western blotting analysis of the HMGA2 level in U87MG and U251 cells infected with control viruses (Con) or HMGA2 expression viruses (HMGA2). n = 3, **, P < .01. B, The migration and invasion of the above GBM cells were detected by transwell assay (left), and infiltrating cell numbers were qualified (right). n = 3, **, P < .01. C, Six‐week‐old NOD‐SCID mice were orthotopically inoculated with U87MG‐Con or U87MG‐HMGA2 cells. n = 5. D, Tumors were measured by IVIS imaging system at 30 days after initial implantation. n = 5, **, P < .01. E, Kaplan‐Meier analysis of the in vivo tumor transplant assay. HMGA2 group had significantly shorter survival time than Con group n = 5, **, P < .01. The data in (A, B, and D) are given in mean ± SD