Table 3.
Comparison of Oral EBV DNA loads in NPC pedigrees and general controls
| Subjects | EBV loads (copies/mL)a | Medianb | Median (IQR)c | P d | |
|---|---|---|---|---|---|
| <33 978, N(%) | ≥33 978, N(%) | ||||
| Healthy controls | 828 (50.00) | 828 (50.00) | 33 978 | 4.53 (3.04‐4.53) | Ref. |
| Unaffected relatives | 82 (49.70) | 83 (50.30) | 34 930 | 4.54 (2.88‐5.68) | .719 |
| Parents | 9 (37.50) | 15 (62.50) | 100 352 | 4.97 (3.13‐6.07) | .142 |
| Offspring | 27 (60.00) | 18 (40.00) | 2064 | 3.31 (2.66‐5.72) | .266 |
| Sibling | 17 (43.59) | 22 (56.41) | 71 519 | 4.85 (2.94‐5.43) | .456 |
| Spouse | 16 (53.33) | 14 (46.67) | 25 269 | 4.39 (3.07‐5.50) | .590 |
| Other relatives | 13 (50.00) | 14 (50.00) | 24 292 | 3.93 (2.43‐5.62) | .556 |
| NPC patients | 65 (71.43) | 26 (28.57) | 4464 | 3.65 (2.85‐4.63) | .004 |
| .040e | |||||
a
Oral EBV loads were assigned into 2 groups based on the median of that in healthy controls (33 978 copies/mL).
b
Median represents the median value of the oral EBV load copy number in per milliliter mouth washing.
c
Median (IQR) represents the log10 transformed median value and interquartile value of oral EBV load copy number in per milliliter mouth washing.
d
Mann‐Whitney U test was used for comparison of oral EBV load between general healthy subjects and NPC pedigree members.
e
Mann‐Whitney U test was used for comparison of oral EBV load between unaffected family members and NPC probands.