Table 2.

Associations between selected polymorphisms in FOCM‐related genes and overall‐ and disease‐free survival

	Gene	SNP	Genotype	HR(95%‐CI)h	P a	pFDR b	pTrend c	pTrend‐FDR d	pGenewide‐FDR e
Overall Survival	PON1	rs3917538	C/C	ref			<0.01	<0.01	<0.01
			C/T	1.18 (0.97–1.43)	0.09
			T/T	2.02 (1.46–2.80)	<0.01
			C/T or T/Tf	1.28 (1.07–1.53)	<0.01	0.59			0.04
	TYMS	rs1001761g	C/C	ref			0.04	0.73	0.11
			C/T	0.84 (0.68–1.02)	0.08
			T/T	0.77 (0.59–1.00)	0.05
			C/T or T/Tf	0.82 (0.68–0.99)	0.04	0.59			0.09
	TYMS	rs2847149g	G/G	ref			0.04	0.73	0.11
			G/A	0.84 (0.68–1.02)	0.08
			A/A	0.77 (0.59–1.00)	0.02
			G/A or A/Af	0.82 (0.68–0.99)	0.04	0.59			0.09
	TYMS	rs495139	C/C	ref			0.07	0.79	0.11
			C/G	1.48 (1.20–1.82)	<0.01
			G/G	1.17 (0.89–1.53)	0.27
			C/G or G/Gf	1.39 (1.14–1.69)	<0.01	0.45			<0.01
Disease‐free survival	MAT2B	rs6882306	T/T	ref			<0.01	0.45	0.01
			T/C	1.31 (1.05–1.62)	0.01
			C/C	1.91 (1.15–3.16)	0.01
			T/C or C/Cf	1.35 (1.10–1.66)	<0.01	0.84			0.02
	UMPS	rs1162	A/A	ref			<0.01	0.60	0.02
			A/G	1.22 (0.99–1.50)	0.06
			G/G	1.57 (1.15–2.13)	<0.01
			A/G or G/Gf	1.29 (1.06–1.57)	0.01	0.84			0.07

^ap:P‐value for log‐additive and dominant model.

^bp_FDR:FDR‐adjusted.

^cp_Trend:P‐value trend.

^dp_Trend‐FDR:FDR‐adjusted trend.

^ep_{Genewide‐FDR}:FDR‐adjusted genewide effect.

^fDominant model, (HR_het).

^gCandidate, FDR‐adjusted cutoff for significance of P‐value = 0.01.

^hAdjusted for age, sex, stage, grade, BMI, alcohol intake.

P‐values in bold are statistically significant.