Table 4.
Associations between age at diagnosis and breast cancer recurrence
| Models | n/event | Hazards ratio (95% CI) | c‐index | ||
|---|---|---|---|---|---|
| 40‐59 | ~39 | 60~ | |||
| Model 1 | 880/86 | 1.00 (reference) | 2.96 (1.54, 5.67) | 1.93 (1.21, 3.08) | 0.61 |
| Model 2 | 822/81 | 1.00 (reference) | 2.81 (1.44, 5.45) | 2.37 (1.45, 3.89) | 0.68 |
| Model 3 | 537/57 | 1.00 (reference) | 2.51 (1.28, 4.89) | 2.49 (1.51, 4.10) | 0.71 |
| Model 4 | 537/57 | 1.00 (reference) | 2.22 (1.06, 4.65) | 1.84 (1.03, 3.37) | 0.69 |
| Model 5 | 535/57 | 1.00 (reference) | 1.97 (0.94, 4.17) | 2.03 (1.11, 3.74) | 0.71 |
| Model 6 | 503/52 | 1.00 (reference) | 1.93 (0.85, 4.39) | 2.11 (1.13, 3.40) | 0.70 |
| Model 7 | 503/52 | 1.00 (reference) | 1.89 (0.84, 4.29) | 2.11 (1.13, 3.96) | 0.70 |
| Model 8 | 503/52 | 1.00 (reference) | 1.84 (0.81, 4.20) | 2.15 (1.15, 4.04) | 0.70 |
| Model 9 | 503/52 | 1.00 (reference) | 1.93 (0.85, 4.34) | 2.12 (1.13, 3.97) | 0.70 |
| Model 10 | 503/52 | 1.00 (reference) | 1.85 (0.82, 4.23) | 2.12 (1.13, 3.98) | 0.70 |
| Model 11 | 503/52 | 1.00 (reference) | 1.89 (0.83, 4.28) | 2.17 (1.16, 4.07) | 0.70 |
| Model 12 | 503/52 | 1.00 (reference) | 1.87 (0.81, 4.32) | 2.13 (1.13, 4.03) | 0.70 |
Model 1, unadjusted; Model 2, adjusted by race, tumor size, node status; Model 3, further adjusted by PAM50 subtype; Model 4, further adjusted by risk stratification; Model 5, further adjusted by DNAm age; Model 6‐11, further separately adjusted by GATA 3, PIK3CA, MLL3, CDH1, TP53, MAP3K1; Model 12 adjusted all the variables.