Figure 6.

ABC294640 and ABT‐199 synergistically induce mitochondrial membrane damage in MM cells. A, JJN3, OPM2, and RPMI8266 cells were treated with indicated concentration for 16 h, either alone or in combination. An increased green fluorescence indicates that mitochondrial membrane depolarization. B, Quantification of green florescence. Results are representative of three independent experiments as the mean ± SD. The P values were calculated between control and combination treatment (*P = .05; **P = .01; and ***P = .001)