Table 4.
Comparing of free and total testosterone and SHBG among different groups using ANOVA and general linear model with univariate analysis (ANCOVA).
| ANOVA | ||||||||
| p value | ||||||||
| Normal | MetS | T2DM without MetS | T2DM with MetS | ANOVA | MetS against normal | T2DM without MetS against normal | T2DM with MetS against normal | |
|
| ||||||||
| Testosterone (ng/ml) | 6.1 (5.5-6.8) | 4.1 (3.7–4.7) | 5.4 (4.8–6.2) | 5.1 (4.4-5.9) | 0.0002 | 8.6 × 10 −5 | 0.5 | 0.15 |
| SHBG (nmol/l) | 40 (36–44) | 29 (25–33) | 32 (27–38) | 33 (29–38) | 0.009 | 0.004 | 0.11 | 0.2 |
| Free testosterone (pmol/l) | 420 (384–457) | 326 (281–372) | 415 (365–468) | 383 (338–430) | 0.01 | 0.015 | 0.999 | 0.66 |
|
| ||||||||
| ANCOVA | ||||||||
| ANCOVA | ||||||||
|
| ||||||||
| Free testosterone® | 361 (310–419) | 348 (303–400) | 377 (334–425) | 400 (352–454) | 0.35 | 0.77 | 0.60 | 0.37 |
| Testosterone# | 5.8 (5.3–6.4) | 4.8 (4.2–5.3) | 5.8 (5.3–6.3) | 5.5 (5.0–6.0) | 0.017 | 0.005 | 0.84 | 0.28 |
| Testosterone& | 5.4 (4.8–6.1) | 5.1 (4.5–5.8) | 5.6 (5.1–6.1) | 5.8 (5.2–6.3) | 0.372 | 0.58 | 0.67 | 0.544 |
| SHBG$ | 40 (34–46) | 28 (24–33) | 37 (32–41) | 37 (32–43) | 0.002 | 0.0003 | 0.41 | 0.56 |
| SHBG∗ | 38 (33–42) | 34 (30–38) | 35 (31–38) | 36 (32–41) | 0.46 | 0.15 | 0.39 | 0.70 |
The results are presented as means and 95% confidence interval; ®general linear model adjusted for waist; #general linear model adjusted for SHBG; &general linear model adjusted for SHBG and waist; $general linear model adjusted for FBG, TG, and age; ∗general linear model adjusted for FBG, TG, age, and testosterone.