Table 2.

Comparison of clinical effect on static wrinkles before and after treatment ($\stackrel{-}{x}\pm S$).

Group	Baseline	1 week	4 weeks	12 weeks
intramuscular injections	1.90 ± 0.55	1.75 ± 0.55bc	1.75 ± 0.55bc	1.80 ± 0.52
intradermal Microdroplet	1.90 ± 0.72	0.90 ± 0.55∗a	0.65 ± 0.49∗a	1.60 ± 0.50∗
nanomicroneedles	2.00 ± 0.65	1.10 ± 0.64∗a	0.85 ± 0.49∗a	1.80 ± 0.41∗
F value	0.257	11.636	26.357	1.152
P value	>0.05	<0.05	<0.05	>0.05

Note: ^∗P < 0.05 compared with baseline; ^aP < 0.05 compared with intramuscular injections group at the same time point; ^bP < 0.05 compared with intradermal microdroplet group at the same time point; ^cP < 0.05 compared with nanomicroneedle group at the same time point.