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. 2018 Jul 3;2018:5207031. doi: 10.1155/2018/5207031

Figure 1.

Figure 1

Knockout of the RBP-J gene. (a) Expression level of the RBP-J protein by western blot analysis. Significant differences were observed between Myh6-RBP-Jfl/wt mice and RBP-Jfl/fl mice (n = 3, ∗P < 0.05). (b&c) mRNA expression of Hes1 and Hey1 by real time PCR. Significant differences in the expression of Hes1 and Hey1 mRNA were observed in the myocardium of Myh6-RBP-Jfl/wt mice and RBP-Jfl/fl mice (n = 3, ∗P < 0.05). (d) Kaplan-Meier analysis showed a significantly lower survival rate in Myh6-RBP-Jfl/wt-MI mice than in RBP-Jfl/fl-MI mice (log-rank: P = 0.045).