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Retrograde GNP-endosomes under load. (A) Unidirectional trajectories of retrograde GNP-endosomes in axons captured by darkfield imaging are shown. The inset shows a snapshot of GNP-endosomes transporting in axons. Scale bars, 3 μm. (B) Gradual stalls and fast reversals (“jumps”) exhibited by GNP-endosomes in axons are shown. (C) The elastic tether model explains the endosome jumps as the gradual stalling and detachment of dyneins under load.
