Table 1.
Clinical features of the studied cohort.
| Healthy controls (n = 16) | SCA 3 patients (n = 17) | P-valueb | Correlation with SCA3-RP LOOCV z-scores in SCA3 patients (coefficients and p-values) | |
|---|---|---|---|---|
| Age, years (range) | 49.4 ± 13.5 (20–65) | 45.3 ± 11.4 (24–62) | 0.36 | r = 0.03; P = 0.91 |
| n Male (%) | 8 (50.0) | 9 (53.9) | 0.87 | |
| Age at onset, years (range) | 35.6 ± 10.2 (20–55) | r = 0.03; P = 0.91 | ||
| Disease duration (range) | 9.7 ± 7 (3−30) | r = 0.05; P = 0.85 | ||
| CAG repeatsa (range) | 70 (65.5–72.5) | ρ = 0.35; P = 0.16 | ||
| SARAa (range) | 0 (0–0.5) | 10 (3.5–15.5) | <0.001⁎ | ρ = 0.75; P = 0.001⁎ |
| Level of educationa | 5.50 (5–6) | 5.0 (5–6) | 0.31 | ρ = −0.28; P = 0.28 |
| Anxiety (HADS) | 4.0 ± 2.4 | 3.5 ± 2.9 | 0.63 | ρ = −0.27; P = 0.29 |
| Depression (HADS) | 1.6 ± 1.5 | 5.3 ± 3.5 | 0.001⁎ | ρ = 0.03; P = 0.90 |
| Semantic Fluency | 26.2 ± 7.8 | 20.0 ± 6.5 | 0.028 | ρ = −0.19; P = 0.46 |
| Letter Fluency | 38.6 ± 11.5 | 24.3 ± 12.0 | 0.001⁎ | ρ = −0.51; P = 0.04 |
| Immediate Recall (RAVLT) | 50.7 ± 9.0 | 42.6 ± 9.5 | 0.021 | ρ = −0.19; P = 0.48 |
| Delayed Recall (RAVLT) | 11.4 ± 3.0 | 8.8 ± 2.8 | 0.010 | ρ = −0.07; P = 0.80 |
| Symbol Digit Modalities Test | 62.5 ± 9.6 | 44.4 ± 8.2 | <0.001⁎ | ρ = −0.24; P = 0.36 |
Values are given as mean ± SD unless otherwise specified.
a
Median (interquartile range).
b
Independent samples t-test for age, Chi2 for gender, Mann-Whitney U test for remaining variables.
⁎
Significant at P < 0.005; RAVLT = Rey Auditory Verbal Learning Test; r = Pearson's r correlation coefficient for parametric variables; ρ = Spearman's rho correlation coefficient for non-parametric variables.