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. 2018 May 14;5(7):1800234. doi: 10.1002/advs.201800234

Figure 2.

Figure 2

Synthesis of the isoUb building blocks: A) Retrosynthetic analysis of diUbs; B) synthesis of key isoUb segment 3; C) analytical HPLC chromatogram of crude product 3; D) analytical HPLC chromatogram of isolated product 3; E) observed ESI‐MS spectrum of the main peak of 3; F) synthesis of key isoUb segment 6; G) analytical HPLC chromatogram of crude product 6; H) analytical HPLC chromatogram of isolated product 6; and I) observed ESI‐MS spectrum of the main peak of 6. Reagents and conditions: a) Pd[P(Ph)3]4, phenylsilane/DCM; b) TFA/phenol/water/thioanisole/1,2‐ethanedithiol (82.5/5/5/5/2.5, v/v). HPLC (λ = 214 nm).