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. 2018 Jul 11;9:1178. doi: 10.3389/fpsyg.2018.01178

FIGURE 1.

FIGURE 1

(A) The subjects tapped the button in synchrony with the sequences of auditory tones presented at fixed interstimulus intervals (ISIs) between 200 and 4800 ms. We measured the time difference [synchronizing tapping error (STE)] between the times of taps (white arrows) and those of tones (black arrows). (B) Examples of the distributions of reaction time and STE in a normal subject, early PD patient, and advanced PD patient. The gray bar indicates the 95% area of the subject’s reaction time. (C) The schematic distributions of a subject’s reaction time and STE at each ISI. When the ISI is short enough, the distribution of STE has a single peak. However, as the ISI gets longer, the distribution of STEs becomes broader, and another peak appears that corresponds to the range of reaction time, which means that the subject taps after hearing the tone (delayed tapping) instead of synchronizing. We estimated the rate of delayed tapping at each ISI by calculating the rate of STE that corresponded to the 95% area of the subject’s reaction time. (D) The method used to calculate the limit of temporal integration of each subject.