Table 2.
Summary of Centiloid analysis on the GAAIN dataset.
| CL_WUSTL | CL_3060_ BP |
CL_3060_ BP_RSF |
CL_4070_ BP |
CL_4070_ BP_RSF |
CL_3060_ SUVr |
CL_3060_ SUVr_RSF |
CL_4070_ SUVr |
CL_4070_ SUVr_RSF |
CL_3060_ SUVr_BS |
CL_3060_ SUVr_RSF _BS |
CL_3060_ SUVr_WC |
CL_3060_ SUVr_RSF _WC |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| YC mean | −0.1 | 0.0 | 1.6 | 0.0 | 1.2 | −0.3 | 0.2 | −0.2 | 0.3 | −0.1 | 0.1 | −0.4 | 0.1 |
| YC SD | 4.2 | 5.6 | 3.3 | 5.3 | 3.1 | 6.1 | 3.7 | 5.2 | 3.3 | 7.3 | 6.1 | 4.8 | 4.0 |
| AD mean | 102.9 | 102.8 | 101.2 | 102.8 | 101.6 | 103.1 | 102.6 | 103.0 | 102.5 | 102.9 | 102.7 | 103.2 | 102.7 |
| R2 | 0.96 | 0.94 | 0.97 | 0.95 | 0.98 | 0.98 | 0.99 | 0.98 | 0.98 | 0.97 | 0.98 | 0.97 | |
| Specificity threshold (95%) | |||||||||||||
| 6.8 | 9.2 | 7.1 | 8.7 | 6.2 | 9.8 | 6.2 | 8.3 | 5.7 | 11.9 | 10.2 | 7.5 | 6.7 | |
| Level of significance | |||||||||||||
| Inter-individual variability | |||||||||||||
| RSFvsNonRSF | ⁎ | ⁎ | ⁎ | ns | ns | ns | |||||||
| BSvsCER | ns | ⁎ | |||||||||||
| WCvsCER | ns | ns | |||||||||||
| 4070vs3060 | ns | ns | ns | ns | |||||||||
| SUVrvsBP | ns | ns | ns | ns | |||||||||
| Comparison of YC mean | |||||||||||||
| RSFvsNonRSF | ns | ns | ns | ns | ns | ns | |||||||
| BSvsCER | ns | ns | |||||||||||
| WCvsCER | ns | ns | |||||||||||
| 4070vs3060 | ⁎⁎ | ⁎⁎ | ⁎⁎ | ⁎⁎ | |||||||||
| SUVrvsBP | ns | ⁎ | ns | ⁎ | |||||||||
ns: nonsignificant; ⁎: p < 0.05; ⁎⁎: p < 0.0005, therefore remain significant after Bonferroni correction for multiple comparisons. The lower portion of the table reports the significance level for pair-wise comparison between different quantification techniques. For comparisons between RSF partial volume corrected methods with their counterparts without RSF PVC (RSFvsNonRSF), the significance level is reported under the RSF column; for comparisons between brainstem referencing methods with their counterparts with the default cerebellar gray referencing (BSvsCER), the significance level is reported under the BS column; for comparisons between whole cerebellum referencing methods with their counterparts with the default cerebellar gray matter referencing (WCvsCER), the significance level is reported under the WC column; For time window comparison (4070vs3060), the significance level is reported under the 4070 column; for comparison between SUVr and BP measurements (SUVrvsBP), the significance level is reported under the SUVr column. It should be noted that comparison for a particular technical variability was only performed between otherwise equivalent techniques.