Table 3.
Summary of Centiloid analysis on the cross-sectional ADRC cohort.
| CL_3060_BP | CL_3060_ BP_RSF |
CL_3060_ SUVr |
CL_3060_ SUVr_RSF |
CL_3060_ SUVr_BS |
CL_3060_ SUVr_RSF _BS |
CL_3060_ SUVr_WC |
CL_3060_ SUVr_RSF _WC |
|
|---|---|---|---|---|---|---|---|---|
| A− Mean | −0.6 | 1.7 | 0.1 | −1.9 | −6.4 | −5.0 | −3.4 | −3.4 |
| A− SD | 4.7 | 3.2 | 5.4 | 4.0 | 7.0 | 5.1 | 5.1 | 4.0 |
| A+ Mean | 56.8 | 52.5 | 66.2 | 61.2 | 58.0 | 54.2 | 61.5 | 55.8 |
| A+ SD | 31.6 | 31.2 | 34.9 | 35.9 | 36.8 | 35.0 | 34.7 | 33.8 |
| RW threshold | ||||||||
| 10.0 | 6.0 | 11.0 | 2.0 | −2.0 | −2.0 | 6.0 | 0.0 | |
| Specificity threshold (95%) (duplicated from Table 2) | ||||||||
| 9.2 | 7.1 | 9.8 | 6.2 | 11.9 | 10.2 | 7.5 | 6.7 | |
| Level of significance | ||||||||
| Inter-individual variability for amyloid negative (A−) participants | ||||||||
| RSFvsNonRSF | ⁎⁎ | ⁎⁎ | ⁎⁎ | ⁎⁎ | ||||
| BSvsCER | ⁎⁎ | ⁎⁎ | ||||||
| WCvsCER | ns | ns | ||||||
| SUVrvsBP | ⁎ | ⁎⁎ | ||||||
| Comparison within A− group | ||||||||
| RSFvsNonRSF | ⁎⁎ | ⁎⁎ | ⁎⁎ | ns | ||||
| BSvsCER | ⁎⁎ | ⁎⁎ | ||||||
| WCvsCER | ⁎⁎ | ⁎⁎ | ||||||
| SUVrvsBP | ⁎⁎ | ⁎⁎ | ||||||
| Comparison within A+ group | ||||||||
| RSFvsNonRSF | ⁎⁎ | ⁎⁎ | ⁎⁎ | ⁎⁎ | ||||
| BSvsCER | ⁎⁎ | ⁎⁎ | ||||||
| WCvsCER | ⁎⁎ | ⁎⁎ | ||||||
| SUVrvsBP | ⁎⁎ | ⁎⁎ | ||||||
ns: nonsignificant; ⁎: p < 0.05; ⁎⁎: p < 0.0005, therefore remain significant after Bonferroni correction for multiple comparisons. The lower portion of the table reports the significance level for pair-wise comparison between different quantification techniques. For comparisons between RSF partial volume corrected methods with their counterparts without RSF PVC (RSFvsNonRSF), the significance level is reported under the RSF column; for comparisons between brainstem referencing methods with their counterparts with the default cerebellar gray referencing (BSvsCER), the significance level is reported under the BS column; for comparisons between whole cerebellum referencing methods with their counterparts with the default cerebellar gray matter referencing (WCvsCER), the significance level is reported under the WC column; For time window comparison (4070vs3060), the significance level is reported under the 4070 column; for comparison between SUVr and BP measurements (SUVrvsBP), the significance level is reported under the SUVr column. It should be noted that comparison for a particular technical variability was only performed between otherwise equivalent techniques.