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. Author manuscript; available in PMC: 2018 Jul 18.
Published in final edited form as: Mol Cell. 2015 Nov 12;60(4):637–650. doi: 10.1016/j.molcel.2015.10.016

Figure 2. Type III pks Cluster-Derived Alkyl benzoquinones from Msmeg Biofilm.

Figure 2

(A) Mycobacterial species containing a type III pks operon in their genomes.

(B) Real-time expression analysis of the pks10 cluster in Msmeg biofilm relative to planktonic culture.

(C) Tandem-MS characterization of the alkyl benzoquinones isolated from Msmeg biofilm.

(D) Biosynthetic pathway for the alkyl benzoquinones.

(E) Autoradiogram of radio-TLC showing product formed by Msmeg PKS10 using different fatty acyl-CoAs as the starter unit and radiolabeled MCoA and/or MMCoA as the extender unit(s).

(F) Quantitation of tetraketide pyrone and tetraketide resorcinol products formed by PKS10 using only MCoA or a mixture of MCoA and MMCoA.

See also Figures S2–S5.