Table 1. Comparison of DHL and DEL (non-DHL) cases.
| Characteristic | DHL (n = 40) | DEL (non-DHL) (n = 58)* | P | P^ |
|---|---|---|---|---|
| Age, years, median (range) | 68 (range 21–88) | 65 (range 30–92) | 0.896 | |
| Gender, male | 21 (53%) | 37 (64%) | 0.265 | |
| IPI at diagnosis, average (range) | 3.4 (range 1–5) | 2.3 (range 0–5) | <0.001 | |
| LDH, U/L, median (range) | 677 (range 107–6411) | 238 (118–11743) | 0.087 | |
| Stage, average (range) | 3.9 (range III-IV) | 3.3 (range I-IV) | 0.008 | |
| Extranodal sites, average (range) | 2.1 (range 0–5) | 1.3 (range 0–5) | 0.003 | |
| Bulky GI disease | 9 (23%) | 10 (17%) | 0.561 | 0.561 |
| Bone marrow | 15 (38%) | 4 (7%) | <0.001 | 0.001 |
| CNS | 7 (18%) | 8 (14%) | 0.490 | 0.561 |
| Remission achieved | 16 (40%) | 28 (48%) | 0.377 | |
| Primary refractory status | 13 (33%) | 17 (29%) | 0.514 | |
| Prior chemotherapy | 3 (8%) | 6 (10%) | 0.633 | |
| Transformed disease | 14 (35%) | 8 (14%) | 0.016 | |
| Tissue size, mm2, median (range) | 52 (3–432 mm2) | 55 (2–432 mm2) | 0.841 | |
| Specimen type | ||||
| Bone marrow | 7 (18%) | 1 (2%) | 0.022 | 0.022 |
| Other tissue | 29 (73%) | 57 (98%) | 0.004 | 0.012 |
| Cytology | 4 (10%) | 0 (0%) | 0.014 | 0.021 |
| Immunophenotype | ||||
| CD20, number positive | 36 (90%) | 56 (97%) | 0.184 | |
| MYC, %, median (range) | 85 (25–100%) | 60 (40–95%) | 0.004 | 0.012 |
| BCL2, %, median (range) | 100 (0–100%) | 98 (55–100%) | 0.850 | 0.850 |
| Ki67, %, median (range) | 75 (20–95%) | 85 (35–100%) | 0.012 | 0.018 |
| CD52, number positive | 30 (75%) | 44 (76%) | 0.920 | |
| Cytogenetics | ||||
| MYC translocation | 40 (100%) | 4 (7%) | <0.001 | |
| BCL2 translocation | 30 (75%) | NA/ND | ||
| BCL6 translocation | 15 (38%) | NA/ND | ||
| Morphology | ||||
| DLCBL | 22 (55%) | 51 (88%) | NA | |
| DLBCL/BL | 7 (18%) | 6 (10%) | NA | |
| Blastoid | 11 (28%) | 1 (2%) | NA |
NA = not applicable; ND = not determined; NOS = not otherwise specified; IPI = International Prognostic Index; GI = gastrointestinal; CNS = central nervous system; LDH = lactate dehydrogenase; DLBCL = diffuse large B-cell lymphoma; BL = Burkitt lymphoma
*MYC-translocated DEL cases were shown to be negative for both BCL2 and BCL6 translocations;
P^ = Family-wise FDR adjusted p-values