Table 4. Physiologic pathways over-represented by mRNA targets of the 11 CircaMiRs.
| KEGG pathway | p-value | #genes | #miRNAs |
|---|---|---|---|
| Rap1 signaling pathway | 7.7E-05 | 30 | 9 |
| Mucin type O-Glycan biosynthesis | 1.5E-03 | 4 | 4 |
| Ras signaling pathway | 2.1E-03 | 30 | 8 |
| Estrogen signaling pathway | 2.1E-03 | 14 | 7 |
| Lysine degradation | 2.5E-03 | 6 | 6 |
| ErbB signaling pathway | 3.3E-03 | 17 | 7 |
| PI3K-Akt signaling pathway | 3.8E-03 | 38 | 9 |
| Proteoglycans in cancer | 4.7E-03 | 23 | 7 |
| Neurotrophin signaling pathway | 4.9E-03 | 19 | 7 |
| Choline metabolism in cancer | 5.2E-03 | 15 | 8 |
| Renal cell carcinoma | 1.2E-02 | 12 | 6 |
| mTOR signaling pathway | 1.5E-02 | 11 | 6 |
| Prolactin signaling pathway | 1.5E-02 | 11 | 7 |
| MAPK signaling pathway | 1.5E-02 | 29 | 8 |
| FoxO signaling pathway | 2.0E-02 | 17 | 7 |
| Long-term potentiation | 2.5E-02 | 11 | 7 |
| Endocytosis | 2.5E-02 | 21 | 8 |
| Focal adhesion | 3.6E-02 | 23 | 8 |
| Oocyte meiosis | 3.6E-02 | 14 | 7 |
| Protein processing in endoplasmic reticulum | 4.6E-02 | 18 | 5 |
| Insulin signaling pathway | 4.6E-02 | 17 | 5 |
| Glutamatergic synapse | 5.0E-02 | 13 | 5 |