Table 2. Significantly enriched metabolic pathways in cervical cancer and associated reporter metabolites.
Metabolic Pathway | p-value | Reporter Metabolites Enriched In the Metabolic Pathway |
---|---|---|
Arachidonic acid metabolism | <10−15 | 5(S)-HETE, 8(S)-HETE, 12(S)-HETE,15(S)-HETE, 5(S)-HPETE, 8(S)-HPETE, (11R)-HPETE, 12(S)-HPETE, 15(S)-HPETE, leukotriene A4, leukotriene B4, arachidonate, 5-oxo-ETE, 5,6-epoxytetraene and hepoxilin A3 |
Peroxisome proliferator-activated receptor (PPAR) signaling pathway | 4.22×10−6 | 8(S)-HETE, 13(S)-HODE and leukotriene B4 |
Glutathione metabolism | 1.83×10−4 | GSH, GSSG, NADPH and NADP+ |
Linoleic acid metabolism | 9.83×10−4 | Arachidonate, 13(S)-HODE and 13(S)-HPODE |
Glycolysis / Gluconeogenesis | 2.38×10−2 | 3-phospho-D-glycerate and 1,3-bisphospho-D-glycerate |