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. 2018 Jul 18;13(7):e0200717. doi: 10.1371/journal.pone.0200717

Table 2. Significantly enriched metabolic pathways in cervical cancer and associated reporter metabolites.

Metabolic Pathway p-value Reporter Metabolites Enriched In the Metabolic Pathway
Arachidonic acid metabolism <10−15 5(S)-HETE, 8(S)-HETE, 12(S)-HETE,15(S)-HETE, 5(S)-HPETE, 8(S)-HPETE, (11R)-HPETE, 12(S)-HPETE, 15(S)-HPETE, leukotriene A4, leukotriene B4, arachidonate, 5-oxo-ETE, 5,6-epoxytetraene and hepoxilin A3
Peroxisome proliferator-activated receptor (PPAR) signaling pathway 4.22×10−6 8(S)-HETE, 13(S)-HODE and leukotriene B4
Glutathione metabolism 1.83×10−4 GSH, GSSG, NADPH and NADP+
Linoleic acid metabolism 9.83×10−4 Arachidonate, 13(S)-HODE and 13(S)-HPODE
Glycolysis / Gluconeogenesis 2.38×10−2 3-phospho-D-glycerate and 1,3-bisphospho-D-glycerate