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. 2018 Jul 18;13(7):e0200717. doi: 10.1371/journal.pone.0200717

Table 3. Reporter receptors of cervical cancer (p < 0.05).

Symbol Name p-value Description
ABL1 ABL Proto-Oncogene 1 3.88×10−3 Involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress.
ATR ATR Serine/Threonine Kinase 8.88×10−16 Phosphorylates checkpoint kinases (CHK1, RAD17 and RAD9) as well as tumor suppressor protein (BRCA1).
CCR6 C-C Motif Chemokine Receptor 6 1.56×10−4 Important for B-lineage maturation and antigen-driven B-cell differentiation, and regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses.
CD86 T-lymphocyte activation antigen CD86 6.24×10−3 Expressed by antigen-presenting cells; the ligand for CD28 antigen and cytotoxic T-lymphocyte-associated protein.
EDNRA Endothelin Receptor Type A 1.02×10−2 G protein-coupled receptor activating a phosphatidylinositol-calcium second messenger system.
EDNRB Endothelin Receptor Type B 7.38×10−5 G protein-coupled receptor activating a phosphatidylinositol-calcium second messenger system.
EGFR Epidermal Growth Factor Receptor 1.31×10−4 Essential for ductal development of the mammary glands.
EPHA4 Ephrin Receptor A4 1.76×10−2 Implicated in mediating developmental events, particularly in the nervous system.
EPHA5 Ephrin Receptor A5 3.88×10−2 Implicated in mediating developmental events, particularly in the nervous system.
EPHB2 Ephrin Receptor B2 1.16×10−2 Previously associated with Prostate Cancer/Brain Cancer Susceptibility, Somatic and Prostate Cancer.
FPR1 Formyl Peptide Receptor 1 2.78×10−2 Mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.
GRIK5 Glutamate Ionotropic Receptor Kainate Type Subunit 5 2.45×10−2 Previously associated with Schizophrenia.
ITPR1 Inositol 1,4,5-Trisphosphate Receptor Type 1 5.95×10−3 Mediates calcium release from the endoplasmic reticulum.
NCOA3 Nuclear Receptor Coactivator 3 2.84×10−3 Previously associated with Breast Cancer and Meningothelial Meningioma.
NR2C1 Nuclear receptor subfamily 2 group C member 1 5.21×10−3 Function in many biological processes such as development, cellular differentiation and homeostasis.
NR2C2 Nuclear Receptor Subfamily 2 Group C Member 2 1.21×10−2 Function in many biological processes such as development, cellular differentiation and homeostasis.
P2RX4 Purinergic Receptor P2X 4 6.05 x10-12 A ligand-gated ion channel with high calcium permeability.
RYK Receptor-Like Tyrosine Kinase 1.41×10−2 Previously associated with Robinow Syndrome, Autosomal Dominant 1 and Multiple Endocrine Neoplasia, Type Iib.