Table 3. Specific canonical pathways identified using the targets of miRNAs modulated by macrophages infected with virulent strain (L. interrogans serovar Copenhageni L1-130).
Core analysis from IPA (Ingenuity Pathway Analysis) software was used to identify significant pathways trough B-H Multiple testing correction log(B-H p-value) >1.3.
| Ingenuity Canonical Pathways | -log(B-H p-value) | Genes in Pathway |
|---|---|---|
| PI3K Signaling in B Lymphocytes | 1.98 | 18/130 |
| NRF2-mediated Oxidative Stress Response | 1.62 | 21/193 |
| IL-8 Signaling | 1.91 | 23/197 |
| Clathrin-mediated Endocytosis Signaling | 1.56 | 21/199 |
| p53 Signaling | 1.70 | 15/111 |
| Ovarian Cancer Signaling | 1.36 | 16/144 |
| Osteoarthritis Pathway | 1.36 | 21/210 |
| Small Cell Lung Cancer Signaling | 1.56 | 12/85 |
| Tec Kinase Signaling | 1.36 | 18/170 |
| Erythropoietin Signaling | 1.62 | 12/81 |
| Macropinocytosis Signaling | 1.62 | 12/81 |
| Epithelial Adherens Junction Signaling | 1.56 | 17/146 |
| Gα12/13 Signaling | 1.36 | 15/131 |
| Regulation of IL-2 in Activated and Anergic T Lymphocytes | 1.36 | 29526 |
| Pancreatic Adenocarcinoma Signaling | 1.36 | 14/118 |
| RAR Activation | 1.88 | 22/190 |