Table 5. Associations between rs7412 (reference/alternative alleles: C/T, MAF=0.08 in European Americans, MAF=0.11 in African Americans) and lipids.
Trait | Meta-Analysis | European Americans | African Americans | ||||||
---|---|---|---|---|---|---|---|---|---|
Beta | SE | p | Beta | SE | p | Beta | SE | p | |
Log RLPC | 0.267 | 0.02 | 2.64×10-32 | 0.264 | 0.027 | 6.01×10-23 | 0.275 | 0.042 | 6.10×10-11 |
Log TG | 0.062 | 0.01 | 3.27×10-09 | 0.080 | 0.01 | 3.88×10-10 | 0.025 | 0.018 | 0.177279 |
HDL-C | 1.170 | 0.32 | 0.0003 | 0.827 | 0.38 | 0.0273 | 2.193 | 0.647 | 7.07×10-4 |
HDL-2 | 0.044 | 0.01 | 0.0003 | 0.032 | 0.02 | 0.00901 | 0.070 | 0.022 | 9.00×10-05 |
HDL-3 | 0.463 | 0.22 | 0.0337 | 0.315 | 0.25 | 0.2113 | 0.909 | 0.436 | 0.0372 |
Log LDL-TG | -0.139 | 0.01 | 5.68×10-39 | -0.138 | 0.012 | 3.39×10-30 | -0.140 | 0.022 | 2.35×10-10 |
LDL-C | -16.581 | 0.817 | 1.20×10-91 | -16.170 | 0.94 | 5.78×10-66 | -17.815 | 1.64 | 1.22×10-27 |
TC | -0.327 | 0.02 | 5.39×10-49 | -0.304 | 0.03 | 3.22×10-32 | -0.393 | 0.04 | 4.07×10-19 |
Non-HDL-C | -0.358 | 0.02 | 1.83×10-52 | -0.326 | 0.03 | 1.22×10-32 | -0.447 | 0.05 | 1.15×10-22 |
Lp(a) | -0.139 | 0.03 | 3.40×10-10 | -0.12 | 0.03 | 3.66×10-05 | -0.165 | 0.03 | 1.32×10-06 |