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. Author manuscript; available in PMC: 2019 May 16.
Published in final edited form as: Bioconjug Chem. 2018 Apr 5;29(5):1646–1658. doi: 10.1021/acs.bioconjchem.8b00144

Figure 7.

Figure 7

(A) PET/CT Imaging. Mice xenografted with two A431 (EGFRhigh) tumors on opposing shoulders were intravenously injected with either 64Cu-NODAGA-GαE35 (Non-blocked) or NODAGA-GαE35 at 102 ± 29-fold molar excess followed by 64Cu-NODAGA-GαE35 5–10 minutes later (Blocked) and imaged via PET/CT at 1 and 2 h post-injection. Coronal and transverse slices through tumors are shown for representative mice (n = 4). (B) PET imaging quantification. Signal in the liver, muscle, tumors, and kidney were quantified using Siemens Inveon research software at 1 and 2 h post-injection (**: p < 0.01).