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. Author manuscript; available in PMC: 2019 May 16.
Published in final edited form as: Bioconjug Chem. 2018 Apr 5;29(5):1646–1658. doi: 10.1021/acs.bioconjchem.8b00144

Figure 8.

Figure 8

Excised tissue analysis of 64Cu-NODAGA-GαE35 with and without blocking by NODAGA-GαE35. Mice (n = 4) xenografted with two A431 (EGFRhigh) tumors on opposing shoulders were intravenously injected either 64Cu-NODAGA-GαE35 (Non-blocked) or NODAGA-GαE35 at 102 ± 29-fold molar excess followed by 64Cu-NODAGA-GαE35 5–10 minutes later (Blocked). Mice were euthanized 2 h post-injection. Tissues or fluid of interest were extracted, weighed, and gamma decay radioactivity measured (%ID/g) (*: p < 0.05; **: p < 0.001).