Table S2. Univariate Cox PH analysis for the risk factors of lung cancer-specific death.
| Variables | Before | After matching | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | ||
| Pathology: IMA | 0.852 | 0.732–0.993 | 0.04 | 1.007 | 0.845–1.201 | 0.934 | |
| Age (years) | 1.011 | 1.01–1.013 | <0.001 | 1.019 | 1.011–1.026 | <0.001 | |
| Male sex | 1.415 | 1.363–1.468 | <0.001 | 1.618 | 1.387–1.889 | <0.001 | |
| Race | |||||||
| Black | 1 | 1 | |||||
| Other | 0.819 | 0.746–0.899 | <0.001 | 0.647 | 0.440–0.952 | 0.027 | |
| White | 0.972 | 0.909–1.039 | 0.397 | 0.859 | 0.669–1.104 | 0.235 | |
| Marriage | |||||||
| Married/partner | 1 | 1 | |||||
| Separated | 1.086 | 1.041–1.133 | <0.001 | 1.001 | 0.842–1.211 | 0.919 | |
| Single | 1.008 | 0.947–1.074 | 0.797 | 1.093 | 0.851–1.403 | 0.487 | |
| Unknown | 0.899 | 0.805–1.005 | 0.060 | 1.800 | 0.499–1.284 | 0.355 | |
| Insurance status | |||||||
| Insured | 1 | 1 | |||||
| Medicaid | 1.246 | 1.132–1.371 | <0.001 | 1.454 | 0.980–2.157 | 0.063 | |
| Uninsured | 1.050 | 0.850–1.297 | 0.652 | 0.826 | 0.205–3.326 | 0.788 | |
| Unknown | 1.482 | 1.423–1.543 | <0.000 | 1.601 | 1.349–1.899 | <0.001 | |
| Operation | |||||||
| Lobectomy | 1 | 1 | |||||
| Pneumonectomy | 2.347 | 2.178–2.529 | <0.001 | 2.408 | 1.702–3.406 | <0.001 | |
| Segmentectomy | 1.016 | 0.900–1.147 | 0.801 | 1.011 | 0.623–1.638 | 0.966 | |
| Wedge | 1.163 | 1.081–1.250 | <0.001 | 1.534 | 1.183–1.989 | 0.001 | |
| Chemotherapy | 1.932 | 1.858–2.008 | <0.001 | 1.763 | 1.478–2.103 | <0.001 | |
| Radiation | 2.607 | 2.494–2.725 | <0.001 | 2.663 | 2.119–3.348 | <0.001 | |
| Treatment | |||||||
| Surgery | 1 | 1 | |||||
| Surgery + CTx | 1.669 | 1.588–1.753 | <0.001 | 1.500 | 1.124–1.853 | <0.001 | |
| Surgery − RTx | 3.070 | 2.838–3.321 | <0.001 | 2.701 | 1.791–4.074 | <0.001 | |
| Trimodality | 2.831 | 2.689–2.982 | <0.001 | 2.905 | 2.222–3.798 | <0.001 | |
| Grade | |||||||
| Low (Grade I/II) | 1 | 1 | |||||
| High (Grade III/IV) | 1.741 | 1.675–1.809 | <0.001 | 1.551 | 1.309–1.837 | <0.001 | |
| Unknown | 1.063 | 1.981–1.153 | 0.137 | 0.879 | 0.667–1.159 | 0.362 | |
| Laterality | 0.851 | ||||||
| Left | 1 | 1 | |||||
| Right | 0.947 | 0.912–0.983 | 0.005 | 0.985 | 0.842–1.152 | ||
| One side | 1.353 | 0.507–3.605 | 0.546 | – | – | ||
| Location | |||||||
| Lower | 1 | 1 | |||||
| Middle | 0.955 | 0.875–1.043 | 0.306 | 1.075 | 0.754–1.533 | 0.688 | |
| Upper | 0.789 | 0.844–0.916 | <0.001 | 0.994 | 0.843–1.173 | 0.943 | |
| Other | 1.634 | 1.486–1.795 | <0.001 | 1.872 | 1.288–2.721 | 0.001 | |
| SPN* | 1.520 | 1.349–1.713 | <0.001 | 1.156 | 0.634–2.108 | 0.636 | |
| Pleura involvement† | |||||||
| No | Ref. | 1 | |||||
| Yes | 1.815 | 1.646–2.002 | <0.001 | 1.198 | 0.637–2.14 | 0.541 | |
| No data | 1.534 | 1.434–1.641 | <0.001 | 1.631 | 1.172–2.27 | 0.004 | |
| Tumor size (mm)* | 1.004 | 1.003–1.004 | <0.001 | 1.003 | 1.003–1.004 | <0.001 | |
| No. of LNs positive | 1.088 | 1.085–1.091 | <0.001 | 1.16 | 1.106–1.215 | <0.001 | |
| No. of LNs resected | 1.002 | 0.999–1.004 | 0.208 | 1.001 | 0.990–1.012 | 0.826 | |
| T stages [2000–2003] | |||||||
| T1 | 1 | 1 | |||||
| T2 | 1.809 | 1.685–1.943 | <0.001 | 2.343 | 1.566–3.507 | <0.001 | |
| T3 | 2.843 | 2.490–3.247 | <0.001 | 4.367 | 2.423–7.873 | <0.001 | |
| T4 | 2.981 | 2.693–3.300 | <0.001 | 4.718 | 2.610–8.527 | <0.001 | |
| T stages [2004–2009] | |||||||
| T1 | 1 | 1 | |||||
| T2 | 2.029 | 1.910–2.155 | <0.001 | 2.727 | 2.122–3.504 | <0.001 | |
| T3 | 3.436 | 3.040–3.884 | <0.001 | 4.246 | 2.726–6.614 | <0.001 | |
| T4 | 2.829 | 2.566–3.120 | <0.001 | 2.845 | 1.802–4.490 | <0.001 | |
| T stage [2010–2014] | |||||||
| T1 | 1 | 1 | |||||
| T2 | 2.111 | 1.892–2.355 | <0.001 | 1.531 | 0.787–2.979 | 0.209 | |
| T3 | 3.525 | 3.100–4.009 | <0.001 | 4.503 | 2.376–8.533 | <0.001 | |
| T4 | 4.299 | 3.589–5.150 | <0.001 | 2.944 | 0.674–12.859 | 0.151 | |
| N stages | |||||||
| N0 | 1 | 1 | |||||
| N1 | 2.850 | 2.718–2.987 | <0.001 | 2.703 | 2.012–3.632 | <0.001 | |
| N2 | 3.390 | 3.238–3.549 | <0.001 | 2.643 | 1.997–3.497 | <0.001 | |
| N3 | 4.592 | 3.634–5.803 | <0.001 | – | – | ||
| Stages [2000–2004] | |||||||
| I | 1 | 1 | |||||
| II | 2.640 | 2.415–2.886 | <0.001 | 1.879 | 1.014–3.481 | 0.045 | |
| IIIA | 3.040 | 2.807–3.292 | <0.001 | 2.533 | 1.755–3.656 | <0.001 | |
| IIIB | 2.995 | 2.723–3.294 | <0.001 | 2.799 | 1.703–4.601 | <0.001 | |
| Stages [2004–2009] | |||||||
| IA | 1 | 1 | |||||
| IB | 1.943 | 1.794–2.105 | <0.001 | 2.555 | 1.965–3.322 | <0.001 | |
| IIA | 3.134 | 2.765–3.553 | <0.001 | 3.3.66 | 1.061–10.679 | 0.039 | |
| IIB | 4.370 | 3.988–4.790 | <0.001 | 5.122 | 3.578–7.333 | <0.001 | |
| IIIA | 4.901 | 4.507–5.329 | <0.001 | 4.723 | 2.909–7.667 | <0.001 | |
| IIIB | 3.943 | 3.557–4.371 | <0.001 | 2.950 | 1.863–4.673 | <0.001 | |
| Stages [2010–2014] | |||||||
| IA | 1 | 1 | – | ||||
| IB | 2.042 | 1.745–2.389 | <0.001 | 1.481 | 0.653–3.358 | 0.347 | |
| II | 8.912 | 2.218 –35.806 | 0.002 | – | – | – | |
| IIA | 4.127 | 3.517–4.843 | <0.001 | 4.300 | 1.692–10.925 | 0.002 | |
| IIB | 4.193 | 3.542–4.964 | <0.001 | 6.130 | 3.047–12.330 | <0.001 | |
| IIIA | 6.617 | 5.773–7.584 | <0.001 | 4.171 | 1.561–11.146 | 0.004 | |
| IIIB | 10.410 | 7.944–13.641 | <0.001 | 18.765 | 2.395–147.02 | 0.005 | |
*, data from the subset recorded from 2004; †, data from the subset recorded from 2010. CI, confidence interval; CTx, chemotherapy; HR, hazards ratio; LN, lymph nodes; RTx, radiation; SPN, solitary pulmonary nodule.