Table 5. Treatment regimens for slow growing nontuberculous mycobacteriosis.

Pathogen	Recommended regimen	Second-line or additional agents
M. avium complex	Azithromycin 250–500 mg daily	Clarithromycin 500 mg twice daily
	Rifabutin 300 mg daily	Rifampin 10 mg/kg daily (max. 600 mg)
	Ethambutol 15 mg/kg daily	Amikacin 10–30 mg/kg once daily or Streptomycin 15 mg/kg daily (max. 1,000 mg)
M. kansasii	Rifabutin 300 mg daily	Rifampin 10 mg/kg daily (max. 600 mg)
	Ethambutol 15 mg/kg daily	Clarithromycin 500 mg twice daily or azithromycin 500 mg daily
	Isoniazid 5 mg/kg daily (max. 300 mg)	Trimethoprim-sulfamethoxazole 960 mg twice daily
		Moxifloxacin 400 mg daily
		Amikacin 10–30 mg/kg once daily or streptomycin 15 mg/kg daily (max. 1,000 mg)
M. marinum	Azithromycin 250–500 mg daily	Rifampin 10 mg/kg daily (max. 600 mg)
	Ethambutol 15 mg/kg daily (consider adding rifabutin 300 mg daily for extensive disease)	Clarithromycin 500 mg twice daily or azithromycin 250–500 mg daily
		Trimethoprim-sulfamethoxazole 960 mg twice daily
		Doxycycline or minocycline 100 mg twice daily
M. haemophilum	Azithromycin 500 mg daily	Rifampin 10 mg/kg daily (max. 600 mg)
	Rifabutin 300 mg daily	Clarithromycin 500 mg twice daily or azithromycin 500 mg daily
	Ciprofloxacin 500 mg twice daily	Trimethoprim-sulfamethoxazole 960 mg twice daily
		Doxycycline 100 mg twice daily