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. Author manuscript; available in PMC: 2018 Jul 19.
Published in final edited form as: Nat Prod Rep. 2018 Jul 18;35(7):660–694. doi: 10.1039/c8np00006a

Fig. 2.

Fig. 2

Generalized mechanism of C–C bond formation by radical SAM enzymes. Catalysis proceeds through three major steps; (1) radical initiation, (2) C–C bond formation, and (3) radical quenching. C–C bond formation may require activation of the acceptor substrate to achieve efficient and specific reactions. In some enzymes, radical quenching does not take place immediately after the C–C bond formation and the radical intermediate is used for complex radical rearrangement reactions. The C–C bonds formed are highlighted in blue ovals.