Skip to main content
. Author manuscript; available in PMC: 2018 Jul 19.
Published in final edited form as: Nat Prod Rep. 2018 Jul 18;35(7):660–694. doi: 10.1039/c8np00006a

Fig. 35.

Fig. 35

Function, structure and mechanism of ThiC. (a) The reaction catalyzed by ThiC. The fate of the AIR atoms is highlighted by balls and colors. (b) Active site structure of A. thaliana ThiC in complex with imidazole ribonucleotide and SAH. The mononuclear metal center is occupied by Zn2+. The unique Fe of the [4Fe–4S] cluster is ligated by a chloride ion. (c) Proposed mechanism of ThiC catalysis.