Non-pharmacological approaches that can control neuroinflammation and produce multiple beneficial effects including prevention and resolution of chronic pain, prevention of neurodegeneration, and repair of cognitive function deficits. Abbreviations: DHA, docosahexaenoic acid; EA, electroacupuncture; EPA, eicosapentaenoic acid; VNS, vagus nerve stimulation; SPMs, specialized pro-resolution mediators; TENS, transcutaneous electrical nerve stimulation; TMS, transcranial magnetic stimulation.