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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Neurobiol Dis. 2018 Jun 1;117:170–180. doi: 10.1016/j.nbd.2018.05.018

Figure 4. Nicotine treatment for one month improves social impairment in Thy1-aSyn mice tested at 6 months of age.

Figure 4

Thy1-aSyn mice treated with vehicle sniffed a beaker with a novel mouse (Mo) for less time than Wt mice treated with vehicle. Vehicle treated Thy1-aSyn mice did not show a preference for exploring a novel mouse (Mo) over an empty beaker (Em), but nicotine administration at 0.4 mg/kg/h for one month restored the interest in a novel mouse. Data are presented as mean ± SEM. Two-way repeated measures ANOVA followed by post hoc Bonferroni t test. *p<0.05, Thy1-aSyn-vehicle compared to Wt-vehicle; ^^p<0.01 compared within the group (empty beaker vs. mouse beaker).