Table 1.

Reagents developed for protein footprinting by FPOP

Reagent	Radical	Wavelength	Mass shift	Target amino acid	Reference
H2O2	·OH	248 nm	+16 Da	C, M, W, Y, F, H, L, I,R, K, V, S, T, P, N…	[6,52]
Na2S2O8	SO4−•	248 nm	+16 Da	M, Y, W, F, E, H, S, P, D, T, K, Q…	[50]
CF3SO2Na	·CF3	248 nm	+68 Da	R, H, K, D, E, S, T, N, Q, G, P, A, V, I, L, F, Y, W	[51]
Iodobenzoic acid	·I	248 nm	+126 Da	Y, H	[48]
Diazirine	Carbene	355 nm	Various	Y, E, D, H, K, C, W, R, Q, M…	[49,53]