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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Neurobiol Dis. 2018 May 30;117:28–41. doi: 10.1016/j.nbd.2018.05.017

Figure 5. MeCP2 and BDNF are increased in striatum of rats that self-administer cocaine.

Figure 5

A) Representative western blot of striatal tissue from rats that self-administered cocaine for 19 days for either 2 or 6h/day. B) Graphic representation of changes in total MeCP2 normalized to GAPDH, *p=0.0447, **p=0.0079. C) Graphic representation of changes in phosphorylated MeCP2 normalized to total MeCP2, p=0.9749, 0.5916. D) Graphic representation of changes in precursor BDNF (proBDNF) normalized to GAPDH, p=0.0852, **p=0.0039. E) Graphic representation of changes in mature BDNF (mBDNF) normalized to GAPDH, p=0.3086, 0.2691. Results are expressed as mean ± SEM, n≥ 3 and were analyzed utilizing One-way ANOVA with Tukey’s multiple comparison test. Sham represents saline control. NS is not statistically significant.

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