Table 1.
Relationships between THC and clinicopathological parameters of 455 breast cancers
| Clinicopathology Characteristics | Number | THC (μmol/L) | P Value |
|---|---|---|---|
| Histopathologic classification | |||
| Non-invasive breast carcinoma | 30 | 196.9 ± 65.8 | 0.457 |
| Invasive breast carcinoma | 425 | 210.6 ± 63.7 | |
| Tumor stage | |||
| T1 | 148 | 181.6 ± 70.4 | 0.000 |
| T2 | 251 | 221.0 ± 56.0 | |
| T3 | 56 | 233.1 ± 54.0 | |
| ER | |||
| Negative | 195 | 227.8 ± 55.5 | 0.005 |
| Positive | 260 | 196.1 ± 66.4 | |
| PR | |||
| Negative | 236 | 225.1 ± 57.3 | 0.01 |
| Positive | 219 | 193.0 ± 66.5 | |
| HER2 | |||
| Negative | 346 | 208.4 ± 64.0 | 0.917 |
| Positive | 109 | 213.5 ± 63.6 | |
| Axillary lymph node | |||
| Negative | 260 | 204.2 ± 66.2 | 0.042 |
| Positive | 195 | 216.9 ± 60.0 | |
| Lymphovascular invasion status | |||
| Negative | 276 | 204.6 ± 65.8 | 0.043 |
| Positive | 179 | 217.4 ± 60.1 | |
| Menopausal status | |||
| Postmenopausal | 251 | 211.2 ± 62.2 | 0.213 |
| Menstrual phase* | 45 | 192.7 ± 70.7 | |
| Follicular phase | 81 | 207.2 ± 68.6 | |
| luteal phase | 78 | 217.1 ± 59.1 |
Note.—THC = total hemoglobin concentration;* There were significant differences between Menstrual phase and luteal phase (P = .042).
Non-invasive breast cancer includes ductal carcinoma in situ;
Invasive breast cancer includes invasive ductal carcinoma, invasive lobular carcinoma and mucinous adenocarcinoma and papillary carcinoma and Malignant lobulated tumor and neuroendocrine cancer.