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Overexpression of Kremen1 reduces Wnt signaling. MDA-MB-231 and PC3 cells were transfected with a Kremen1 expression construct or empty vector control, along with Wnt reporter vectors. The ratio of TOPFlash to FOPFlash luciferase activity (TOP:FOP) indicated relative Wnt signaling activity. (* = P < .05; ** = P < .01).
