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. 2018 Jul 18;9:2801. doi: 10.1038/s41467-018-05078-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Phosphorylated EZH2 (T367) is expressed in the cytoplasm of invasive breast carcinoma and distant metastases. a Immunohistochemical analysis of pEZH2(T367) expression using a specific antibody in human tissue samples of 193 patients. Pictures show a representative invasive breast carcinoma with adjacent normal breast (left) and metastasis (right) (×400 magnification). Insets show expression of pEZH2(T367) in cancer cells (×600 magnification). b Results are tabulated. Cytoplasmic pEZH2 is significantly associated with invasive carcinoma and metastasis compared to normal and fibrocystic changes (Chi-square p < 0.00001)