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. 2018 Jul 18;8:10898. doi: 10.1038/s41598-018-29170-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Yearly progression of fat replacement in individual muscles of symptomatic patients. (A) Each dot represents fat fraction calculated in a single muscle. Vertical lines divide muscles based on baseline fat fractions: low (green dots, 0–30%), intermediate (red dots, 30–60%) and severe (orange dots, 60–90%). (B) Increase in muscle fat replacement related to baseline fat fraction. The box plot includes the 25^th–75^th percentile, the mid lines indicate the median, bars correspond to the 5^th–95^th percentiles. Black dots are outliers. Kruskal-Wallis test, *P < 0.05, **P < 0.01.