Table 2.

Mean kinetic parameters of ceftizoxime in milk of healthy goats following single dose intravenous of ceftriaxone at 42.25 mg kg⁻¹.

Kinetic Parameters	Gr –I (healthy goats)
${\mathrm{C}}_{\mathrm{M}}^0$ (µg ml−1)	1046.108 ± 119.031
α (hr−1)	0.054 ± 0.008
β (hr−1)	0.005 ± 0.00057
t1/2α (hr)	14.755 ± 2.733
t1/2β (hr)	149.079 ± 18.565
AUC (µg hr ml−1)	100206.30 ± 6824.54
MRT (hr)	300.923 ± 89.273
CLM (L kg−1 hr−1)	4.48 × 10− ± 0.909 × 10−5
Vdarea (L kg−1)	0.00683 ± 0.00047
Cmax (µg ml−1)	404.831 ± 24.107

${\mathrm{C}}_{\mathrm{M}}^0$, theoretical zero time milk drug concentration; α, rate constant related to slope of absorption curve; β, rate constant related to slope of elimination curve; t½ α and t½ β, half-lives of the drug in absorption and elimination phases, respectively; AUC, total area under the milk drug concentration versus time curve from 0 to t α after administration of a single dose; MRT, minimum residential time; Cl_M: total mammary gland clearance of drug; Vd_area, apparent volume of distribution of the drug on the total area under milk drug concentration versus time curve; C_max, maximum milk drugs concentration.