Table 1.
Candidate epigenetic factors of the Kcnq1ot1 imprinted domain
| Candidate | Gene name | Total colonies | Number of shRNAs |
|---|---|---|---|
| Ezh1 | Enhancer of zeste 1 | 21 | 1 |
| Smarca5 | Smarca subfamily a, member 5 | 16 | 1 |
| Trdmt1 | tRNA aspartic acid methyltransferase 1 (Dnmt2) | 15 | 1 |
| Taf6l | TATA-box binding protein associated factor 6 like | 11 | 1 |
| Smarcc2 | Smarca subfamily c, member 2 | 9 | 4 |
| Smarce1 | Smarca, subfamily e, member 1 | 9 | 2 |
| Nup107 | Nucleoporin 107 | 9 | 1 |
| Atrx | Alpha thalassemia/mental retardation syndrome X-linked | 9 | 1 |
| Smarcad1 | Smarca subfamily a, containing DEAD/H box 1 | 8 | 3 |
| Kat2a | K(lysine) acetyltransferase 2A | 8 | 1 |
| Mbd4 | Methyl-CpG binding domain protein 4 | 7 | 1 |
| Kdm4a | Lysine (K)-specific demethylase 4A | 7 | 1 |
| Smarce1-ps1 | Smarca, subfamily e, member 1 pseudogene 1 | 6 | 2 |
| Kat7 | K(lysine) acetyltransferase 7 | 6 | 2 |
| Suv420h1 | Suppressor of variegation 4-20 homolog 1 | 6 | 1 |
| Mbd3 | Methyl-CpG binding domain protein 3 | 6 | 1 |
| Hdac9 | Histone deacetylase 9 | 5 | 2 |
| Hdac1 | Histone deacetylase 1 | 5 | 1 |
| Sin3a | Transcriptional regulator, SIN3A | 4 | 2 |
| Dnmt3a | DNA methyltransferase 3A | 4 | 2 |
| Smyd3 | SET and MYND domain containing 3 | 4 | 1 |
| Sirt1 | Sirtuin 1 | 3 | 3 |
| Rnf2 | Ring finger protein 2 | 3 | 3 |
| Ezh2 | Enhancer of zeste 2 | 3 | 2 |
| Pcgf6 | Polycomb group ring finger 6 | 3 | 1 |
| Kat6b | K(lysine) acetyltransferase 6B | 3 | 1 |
| Snx10 | Sorting nexin 10 | 3 | 1 |
| Dnmt1 | DNA methyltransferase 1 | 2 | 2 |
| Hdac2 | Histone deacetylase 2 | 2 | 2 |
| Smarcd2 | Smarca subfamily d, member 2 | 2 | 2 |
| Ep300 | E1A binding protein p300 | 2 | 1 |
| Hltf | Helicase-like transcription factor (Smarca3) | 2 | 1 |
| Hdac8 | Histone deacetylase 8 | 2 | 1 |
| Eed | Embryonic ectoderm development | 2 | 1 |
| Taf5l | TATA-box binding protein associated factor 5 like | 1 | 1 |
| Phc3 | Polyhomeotic-like 3 | 1 | 1 |
| Kat2b | K(lysine) acetyltransferase 2B | 1 | 1 |
| Kmt2d | Lysine (K)-specific methyltransferase 2D | 1 | 1 |
| Hdac5 | Histone deacetylase 5 | 1 | 1 |
| Hdac7 | Histone deacetylase 7 | 1 | 1 |
| Smarca1 | Smarca subfamily a, member 1 | 1 | 1 |
aSmarc, SWI/SNF-related, matrix associated actin-dependent regulator of chromatin