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. 2018 Jul 18;8:10872. doi: 10.1038/s41598-018-28948-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Leaf-level GO terms may initially have broad GO headers that do not convey enough information about a leaf-level term. The leaf-level GO term cellular response to interferon-beta (green) has three potential GO headers (top three GO terms with a blue border) that are extremely broad. Even response to stimulus is broad because its descendants are as diverse as response to gravity, startle response, and immune response. The user may wish to add a new GO header which better represents cellular response to interferon-beta, like response to cytokine (circled in blue). Colors in the GO term boxes indicate if one (purple) or more (green) tools found a GO term significant. GOATOOLS, DAVID6.8, and GOstats found cellular response to interferon-beta (green) significant. GOstats found the broad terms, biological_process, cellular process, and response to stimulus significant (purple). The blue GO term borders indicate that a GO term is also a GO header. Of the GO terms pictured here, only biological_process is found in the GO slims as of April 2018. The depth-01 GO terms are default header GO terms because GOATOOLS grouping adds all depth-01 GO terms to the list of default headers.