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. 2018 Jul 18;8:10843. doi: 10.1038/s41598-018-29203-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Triptolide reversed podocyte foot process effacement in MTZ-treated Tg(pod:gal4;UAS:NTR-mCherry) zebrafish. (A) Electron micrograph of normal glomerular vascular loop morphology and foot process development at 6 dpf in wild-type larvae. (B) Glomerular morphology of zebrafish treated with MTZ for 24 h. At low magnifications, an enlarged space outside of Bowman’s capsule was observed, indicating oedema (B1, indicated by #). Extensive foot process effacement was observed at higher magnifications (B3, indicated by arrows). (C) Triptolide prevented most foot process effacement. (n = 3). *Capillary that was magnified. podo, podocyte; cap, capillary space; BS, Bowman’s space; NC, notochord. Scale bar = 10 μm (A1,B1,C1), 2 μm (A2,B2,C2), 1 μm (A3,B3,C3).