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. 2018 Jul 18;8:10843. doi: 10.1038/s41598-018-29203-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Triptolide suppressed podocyte apoptosis. (A) 84 hpf larvae treated with MTZ for 24 h exhibit remarkable podocyte apoptosis signalling compared to the untreated group (CTL) on immunostains against cleaved caspase-3. The number of apoptotic cells was significantly reduced in the triptolide treatment group. (B) Quantification of caspase-3-stained area (green) to mCherry (red). Data are expressed as the means ± SEM. The confocal images are shown at a maximum intensity projection. (n = 3), **P < 0.01; *P < 0.05. (Original magnification, x1000). (C) Annexin V-FITC/PI staining followed by FCM showed podocytes apoptosis induced by PAN was alleviated by triptolide. **P < 0.01. (On the basis of three triplicate tests).